Figure 13

Cell state stability for models 2 and 4 run over varying cell-cell adhesive values. Cell state stability of Model 2 and Model 4. Each graph cell shows the average of 40 randomized runs. The probability of a cell changing its state as a function of homotypic adhesive strength is calculated by examining the last 30 model iterations and determining the proportion that involved any cell state change. The last 30 model iterations correspond in Model 2 to a period when the defect rate is stable and in Model 4 to a period when cell rearrangement is producing no defect cells and therefore no cell death.